La salute del cuore

  • https://www.lifeextension.com/magazine/2019/ss/coq10-continues-to-impress 
  • https://www.lifeextension.com/magazine/2022/3/omega-3-levels-healthy-years 
  • https://www.lifeextension.com/magazine/2021/3/magnesium-benefits-heart-health
  • https://www.lifeextension.com/magazine/2021/11/vitamin-k-whole-body-benefits 
  • https://www.lifeextensioneurope.com/blog/vascular-vitality-and-boosting-endothelial-function/ 
  • https://www.lifeextension.com/wellness/lifestyle/strengthen-heart-muscle
  • https://www.lifeextensioneurope.com/chol-support 
  • https://www.lifeextension.com/wellness/lifestyle/strengthen-heart-muscle 
  • https://www.lifeextension.com/magazine/2023/7/longevity-effects-of-taurine 
  • https://www.lifeextensioneurope.com/tmg

Acido R-lipoico

  • https://www.lifeextension.com/magazine/2014/5/how-lipoic-acid-preserves-critical-mitochondrial-function
  • Available at: http://www.thorne.com/altmedrev/.fulltext/11/3/232.pdf. Accessed February 24, 2014.
  • Smith JR, Thiagaraj HV, Seaver B, Parker KK. Differential activity of lipoic acid enantiomers in cell culture. J Herb Pharmacother. 2005;5(3):43-54.
  • Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol. 1997 Jul;273(1 Pt 1):E185-91.
  • https://www.lifeextension.com/magazine/2021/1/how-lipoic-acid-reduces-body-fat


  • https://www.lifeextension.com/magazine/2021/ss/ampk-belly-fat
  • https://www.lifeextension.com/magazine/2018/ss/turn-on-your-bodys-youth-switch
  • Stenesen D, Suh JM, Seo J, et al. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab. 2013 Jan 8;17(1):101-12.

Arancio orange

  • Azzini E, Giacometti J, Russo GL. Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies. Oxid Med Cell Longev. 2017;2017:2740364.
  • de Lima LP, de Paula Barbosa A. A review of the lipolytic effects and the reduction of abdominal fat from bioactive compounds and moro orange extracts. Heliyon. 2021 Aug;7(8):e07695.
  • https://www.lifeextension.com/magazine/2022/10/shed-belly-fat-mediterranean-way


  • Deshpande A, Irani N, Balkrishnan R, et al. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020 Aug;72:28-36.
  • https://www.lifeextension.com/magazine/2021/7/ashwagandha-brain-benefits


  • Mahabir S, Spitz MR, Barrera SL, et al. Dietary boron and hormone replacement therapy as risk factors for lung cancer in women. Am J Epidemiol. 2008;167(9):1070-80. 
  • Gallardo-Williams MT, Chapin RE, King PE, et al. Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice. Toxicol Pathol. 2004;32(1):73-8. 3. 
  • Gorustovich AA, Steimetz T, Nielsen FH, et al. A histomorphometric study of alveolar bone modelling and remodelling in mice fed a boron-deficient diet. Arch Oral Biol. 2008;53(7):677-82. 
  • https://www.lifeextension.com/magazine/2021/11/what-is-boron
  • https://www.lifeextension.com/magazine/2015/11/boron-reduces-prostate-cancer-risk
  • https://www.lifeextension.com/magazine/2022/2/better-night-sleep
  • https://www.lifeextension.com/magazine/2023/8/challenges-of-male-aging

Coenzima Q10

  • https://www.lifeextension.com/magazine/2008/2/alleviating-congestive-heart-failure-with-coenzyme-q10
  • https://www.lifeextension.com/magazine/2007/ss/enhanced-absorption-ubiquinol-coq10
  • https://www.lifeextension.com/magazine/2023/1/coq10-in-aging
  • https://www.lifeextension.com/magazine/2019/6/coq10-reverses-skin-aging
  • https://www.lifeextension.com/magazine/2021/6/coq10-more-than-just-heart-health
  • https://www.lifeextension.com/magazine/2013/1/coq10-the-longevity-factor
  • https://www.lifeextension.com/magazine/2019/ss/coq10-continues-to-impress
  • https://www.lifeextension.com/wellness/aging/coq10-benefits-for-women


  • https://www.lifeextension.com/magazine/2019/1/magnesium-the-overlooked-mineral Available at: https://ods.od.nih.gov/factsheets/magnesium-healthprofessional. Accessed October 2, 2018.
  • Castiglioni S, Cazzaniga A, Albisetti W, et al. Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions. Nutrients. 2013 07/31; 06/18/received; 07/14/revised; 07/22/accepted;5(8):3022-33.
  • Grober U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015 Sep;7(9):8199-226.
  • Liu G, Weinger JG, Lu ZL, et al. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-90. 
  • Cole JH, Leech R, Sharp DJ. Prediction of brain age suggests accelerated atrophy after traumatic brain injury. Ann Neurol. 2015 Apr;77(4):571-81.
  • Liem F, Varoquaux G, Kynast J, et al. Predicting brain-age from multimodal imaging data captures cognitive impairment. Neuroimage. 2017 Mar 1;148:179-88.
  • Lin L, Jin C, Fu Z, et al. Predicting healthy older adult's brain age based on structural connectivity networks using artificial neural networks. Comput Methods Programs Biomed. 2016 Mar;125:8-17.
  • Luders E, Cherbuin N, Gaser C. Estimating brain age using high-resolution pattern recognition: Younger brains in long-term meditation practitioners. Neuroimage. 2016 Jul 1;134:508-13.


  • Smaga I, Frankowska M, Filip M. N-acetylcysteine as a new prominent approach for treating psychiatric disorders. Br J Pharmacol. 2021 Jul;178(13):2569-94.
  • Salamon S, Kramar B, Marolt TP, et al. Medical and Dietary Uses of N-Acetylcysteine. Antioxidants (Basel). 2019 Apr 28;8(5).
  • https://www.lifeextension.com/magazine/2022/7/benefits-of-n-acetyl-l-cysteine
  • Salamon S, Kramar B, Marolt TP, et al. Medical and Dietary Uses of N-Acetylcysteine. Antioxidants (Basel). 2019 Apr 28;8(5).
  • Sansone RA, Sansone LA. Getting a Knack for NAC: N-Acetyl-Cysteine. Innov Clin Neurosci. 2011 Jan;8(1):10-4.
  • https://www.lifeextension.com/magazine/2020/ss/protect-your-respiratory-system Kalyuzhin OV. Effect of N-acetylcysteine on mucosal immunity of respiratory tract. Ter Arkh. 2018 Apr 19;90(3):89-95.
  • Santus P, Corsico A, Solidoro P, et al. Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine. COPD. 2014 Dec;11(6):705-17.
  • Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018 Jul;52(7):751-62.
  • Zheng CH, Ahmed K, Rikitomi N, et al. The effects of S-carboxymethylcysteine and N-acetylcysteine on the adherence of Moraxella catarrhalis to human pharyngeal epithelial cells. Microbiol Immunol. 1999;43(2):107-13.
  • Riise GC, Qvarfordt I, Larsson S, et al. Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro. Respiration. 2000;67(5):552-8.
  • Cu A, Ye Q, Sarria R, et al. N-acetylcysteine inhibits TNF-alpha, sTNFR, and TGF-beta1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro. Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):147-54.


  • Brozmanova J. Selenium and cancer: from prevention to treatment. Klin Onkol. 2011;24(3):171-9. 
  • Naithani R. Organoselenium compounds in cancer chemoprevention. Mini Rev Med Chem. 2008 Jun;8(7):657-68. 
  • Clark LC, Combs GF, Jr., Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996 Dec 25;276(24):1957-63. 
  • Ganther HE. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. 
  • Available at: https://img1.wsimg.com/blobby/go/719531d1-4d4f-427d-9915-daa0f2e0517b/downloads/Selenase%20IV.pdf?ver=1596487410147. Accessed August 4, 2020. 
  • Jenkins DJA, Kitts D, Giovannucci EL, et al. Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2020 Dec 10;112(6):1642-52. 
  • Zimmermann T, Leonhardt H, Kersting S, Albrecht S, Range U, Eckelt U. Reduction of postoperative lymphedema after oral tumor surgery with sodium selenite. Biol Trace Elem Res. 2005 Sep;106(3):193-203. 
  • Fleet JC. Dietary selenium repletion may reduce cancer incidence in people at high risk who live in areas with low soil selenium. Nutr Rev. 1997 Jul;55(7):277-9. 
  • https://www.lifeextension.com/magazine/2015/11/how-to-obtain-optimal-benefits-from-selenium https://www.lifeextension.com/magazine/2022/12/selenium-research-highlight


  • https://www.lifeextension.com/magazine/2004/12/qanda
  • Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22.
  • Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr. 2003 May;133(5):1291-5.
  • Holm PI, Ueland PM, Vollset SE, et al. Betaine and folate status as cooperative determinants of plasma homocysteine in humans. Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):379-85.
  • Olthof MR, Vliet TV, Verhoef P, Zock PL, Katan MB. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med. 2005 May;2(5):e135.
  • da Costa KA, Gaffney CE, Fischer LM, Zeisel SH. Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr. 2005 Feb;81(2):440-4.
  • https://www.lifeextension.com/magazine/2006/10/report_homocysteine

Vitamina D

  • https://www.lifeextension.com/magazine/2019/4/vitamin-d-improves-vascular-function
  • https://www.lifeextension.com/magazine/2021/7/vitamin-d-magnesium-connection 
  • Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev. 2008 Mar;13(1):6-20.
  • Rosanoff A, Dai Q, Shapses SA. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv Nutr. 2016 Jan;7(1):25-43.
  • Erem S, Atfi A, Razzaque MS. Anabolic effects of vitamin D and magnesium in aging bone. J Steroid Biochem Mol Biol. 2019 Oct;193:105400.
  • Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019 Jan/Feb;26(1):e124-e32. • Wintermeyer E, Ihle C, Ehnert S, et al. Crucial Role of Vitamin D in the Musculoskeletal System. Nutrients. 2016 Jun 1;8(6).

Vitamina E

  • Trivedi JS, Krill SL, Fort JJ. Vitamin E as a human skin penetration enhancer. Eur J Phann Sci. 1995;3:241-3.
  • Brigelius-Floh R, Traber MG. Vitamin E: function and metabolism. FASEB. 1999 Jul;13(10):11455.
  • Clarke MW, Burnett JR, Croft KD. Vitamin E in human health and disease. Crit Rev Clin Lab Sci. 2008;45(5):417-50.
  • Shibata A, Nakagawa K, Kawakami Y, Tsuzuki T, Miyazawa T. Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. J Agric Food Chem. 2010 Jun 9;58(11):7013-20.